Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyaluronate in vasculogenesis.

R N Feinberg, D C Beebe

    Science (New York, N.Y.)
    |June 10, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Hyaluronic acid, a component found in embryonic limb buds, can induce avascular zones when present in high concentrations. This suggests hyaluronic acid plays a role in regulating blood vessel development in embryos.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mitochondrial oxygen metabolism in primary human lens epithelial cells: Association with age, diabetes and glaucoma.

    Free radical biology & medicine·2016
    Same author

    Changes in adhesion complexes define stages in the differentiation of lens fiber cells.

    Investigative ophthalmology & visual science·2001
    Same author

    Alpha-smooth muscle actin expression in cultured lens epithelial cells.

    Investigative ophthalmology & visual science·2001
    Same author

    The lens organizes the anterior segment: specification of neural crest cell differentiation in the avian eye.

    Developmental biology·2001
    Same author

    Apoptosis in early ocular morphogenesis in the mouse.

    Brain research. Developmental brain research·1999
    Same author

    Human age-related cataract and lens epithelial cell death.

    Investigative ophthalmology & visual science·1998
    Same journal

    Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

    Science (New York, N.Y.)·2026
    Same journal

    Local signals, systemic decline.

    Science (New York, N.Y.)·2026
    Same journal

    The mechanics of liver regeneration.

    Science (New York, N.Y.)·2026
    Same journal

    Computing in a memory with physics.

    Science (New York, N.Y.)·2026
    Same journal

    Retraction.

    Science (New York, N.Y.)·2026
    Same journal

    Making time.

    Science (New York, N.Y.)·2026
    See all related articles

    Area of Science:

    • Developmental biology
    • Embryology
    • Tissue engineering

    Background:

    • Embryonic limb buds contain an avascular zone rich in hyaluronic acid within the peripheral mesoderm.
    • The precise role of hyaluronic acid in embryonic vascular development is not fully understood.

    Purpose of the Study:

    • To investigate the role of hyaluronic acid in avascular zone formation within embryonic limb buds.
    • To determine if hyaluronic acid influences blood vessel patterning in developing avian embryos.

    Main Methods:

    • Implantation of epithelial tissues with varying hyaluronic acid synthesis levels into chick wing mesoderm.
    • Utilizing Elvax implants loaded with hyaluronic acid or other glycosaminoglycans.

    Main Results:

    Related Experiment Videos

    • Epithelia synthesizing high levels of hyaluronic acid induced avascularity in the host mesoderm.
    • Epithelia with low hyaluronic acid synthesis did not cause avascularity.
    • Elvax implants containing hyaluronic acid created avascular zones, unlike those with other glycosaminoglycans.

    Conclusions:

    • Hyaluronic acid can induce avascular zones, suggesting a role in inhibiting blood vessel formation.
    • Findings indicate hyaluronic acid may be a key factor in determining blood vessel localization during embryonic development.