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[Effect of antacids on intestinal motility]
Zeitschrift Fur Gastroenterologie
|March 1, 1983
Summary
High-dose antacids disrupt gut motility, causing diarrhea or constipation due to specific cation effects. Magnesium often causes diarrhea through osmotic-secretory actions, while aluminum leads to constipation.
Area of Science:
- Gastroenterology
- Pharmacology
- Physiology
Context:
- High-dose antacid regimens are commonly prescribed for acid-related gastrointestinal disorders.
- Antacid-induced gut motility disturbances, including diarrhea and constipation, are frequent clinical observations.
Purpose:
- To elucidate the mechanisms by which antacid cations influence gastrointestinal motility.
- To differentiate the specific motor effects of aluminum, magnesium, and calcium cations on the gut.
Summary:
- Antacid cations significantly impact gut motility; aluminum inhibits motor activity, while magnesium stimulates muscle contractions but can also activate inhibitory nerves.
- Diarrhea associated with high-dose antacids is primarily attributed to osmotic-secretory effects.
- Calcium exhibits no definitive motor effect on the gut.
Impact:
- Provides a mechanistic understanding of antacid-related gastrointestinal side effects.
- Informs clinical practice regarding the selection and use of antacids to minimize motility disturbances.
- Highlights the importance of considering cation-specific effects in managing patients on long-term antacid therapy.