Multiple meningiomas. Report of nine cases

Area of Science:

• Neurosurgery
• Oncology
• Pathology

Background:

• Multiple meningiomas are rare, accounting for 1-3% of all meningiomas.
• Distinguishing true multiple meningiomas from recurrences or neurofibromatosis variants remains challenging.
• Computed Tomography (CT) has improved diagnosis but not fully resolved nosological issues.

Observation:

• This report details nine cases of multiple meningiomas treated between 1968-1981.
• Cases were categorized into simultaneous, successive, and neurofibromatosis-associated multiple meningiomas.
• Only five of the nine cases were classified as true multiple meningiomas.

Findings:

• Four simultaneous and one successive case were identified as true multiple meningiomas.
• The study discusses pathogenetic factors for true multiple meningiomas.
• Current hypotheses do not definitively explain the multicentricity of these tumors.

Implications:

• Further research is needed to understand the etiology of true multiple meningiomas.
• Improved diagnostic criteria may help differentiate true multiple meningiomas from other conditions.
• Understanding the pathogenesis is crucial for future treatment strategies.