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Methyldopa-induced pancreatitis.

J M Rominger, J G Gutierrez, D Curtis

    The American Journal of Digestive Diseases
    |August 1, 1978
    PubMed
    Summary
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    Methyldopa can cause acute pancreatitis, leading to gastrointestinal upset, fever, and elevated digestive enzymes. Symptoms resolved upon drug discontinuation and returned upon reintroduction, confirming methyldopa as the cause.

    Area of Science:

    • Gastroenterology
    • Clinical Pharmacology

    Background:

    • Methyldopa is a commonly prescribed antihypertensive medication.
    • Gastrointestinal upset is a known potential side effect of methyldopa therapy.

    Observation:

    • A patient developed acute febrile illness with gastrointestinal symptoms shortly after initiating methyldopa.
    • Symptoms improved upon methyldopa withdrawal and recurred upon rechallenge.

    Findings:

    • The patient presented with hyperamylasemia, hyperlipasemia, hyperpyrexia, and epigastric pain.
    • This case documents methyldopa-induced pancreatitis, a rare but significant adverse effect.

    Implications:

    • Clinicians should consider pancreatitis in patients on methyldopa presenting with relevant symptoms.

    Related Experiment Videos

  • This highlights the importance of recognizing drug-induced pancreatitis for timely diagnosis and management.