Related Experiment Videos
Postoperative dreaming. A comparison of the incidence following pentazocine and morphine premedication
Anaesthesia
|May 1, 1983
Abstract:
The incidence of postoperative dreaming following the use of morphine and pentazocine as premedicants in an otherwise standard anaesthetic sequence is compared in healthy volunteers. No statistically significant difference was demonstrated between the two drugs. The causes of psychotomimetic problems in the postoperative period and the difficulty of precise definition of hallucinations are discussed.
Insights
Postoperative dreaming incidence did not differ between morphine and pentazocine premedicants in healthy volunteers. Further discussion addresses psychotomimetic issues and hallucination definition challenges.
Area of Science:
- Anesthesiology
- Pharmacology
- Psychiatry
Background:
- Preoperative medication influences the patient's postoperative experience.
- Opioid analgesics like morphine and pentazocine are commonly used for pre-anesthetic medication.
- Postoperative dreaming and psychotomimetic effects are potential adverse events.
Purpose of the Study:
- To compare the incidence of postoperative dreaming between morphine and pentazocine when used as premedicants.
- To explore the underlying causes of postoperative psychotomimetic phenomena.
- To discuss the challenges in defining and quantifying hallucinations in a clinical setting.
Main Methods:
- A comparative study involving healthy volunteers.
- Administration of morphine or pentazocine as part of a standard anesthetic sequence.
- Assessment of postoperative dreaming incidence.
Main Results:
- No statistically significant difference in postoperative dreaming was observed between the morphine and pentazocine groups.
- The study provides a direct comparison of these two commonly used premedicants regarding a specific side effect.
Conclusions:
- Morphine and pentazocine appear to have similar effects on postoperative dreaming in this context.
- Further research may be needed to fully understand and mitigate postoperative psychotomimetic effects and improve the definition of hallucinations.