Glycine uptake by erythrocytes in iron deficiency anemia

Glycine uptake by erythrocytes from cases of iron deficiency anemia, megaloblastic anemia, and anemia of chronic renal failure and hypothyroidism has been studied. Concentrative uptake, characteristically observed only in iron deficiency, is dependent on a favorable Na+ gradient and is inhibited by p-chloromercuribenzoate. Transport appears to be mediated by a carrier whose possible relation to iron deficiency is discussed.