[Distribution of antibodies to DNA in the tissues of rats with sarcoma-45]

Distribution of a label was studied in nuclear fraction and in tissues of rats with transplanted sarcoma 45 within a day after an administration of immune and nonimmune 131I-gamma-globulins. When gamma-globulins, containing antibodies to one-stranded DNA, were administered the more intensive accumulation of the label was observed in nuclei of malignant tissue as compared with other tissues (liver, heart, thymus and muscles). The diffuse distribution of the label was found if nonimmune gamma-globulins were used. The phenomenon was apparently related to the active penetration of labelled antibodies to the replicating matrix and binding of them with one-stranded DNA sites. The suggestion is discussed that the effect of accumulation of immune gamma-globulin in proliferating tissue might be used for depression of the proliferative process.