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Experience with a screening method for laxative abuse.

F A de Wolff, P M Edelbroek, E J de Haas

Human Toxicology

|April 1, 1983

Summary

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Chronic laxative abuse can cause serious health issues and is often overlooked. A new urine screening method effectively diagnoses laxative poisoning by detecting specific compounds in patient samples.

Area of Science:

Toxicology
Clinical Chemistry
Gastroenterology

Background:

Laxative abuse can lead to diverse and difficult-to-diagnose disorders due to varied toxic effects.
Chronic laxative poisoning is a common yet often unrecognized condition.

Purpose of the Study:

To develop and implement a laboratory screening method for diagnosing chronic laxative poisoning.
To identify specific colonic stimulants in urine samples of suspected patients.

Main Methods:

A laboratory screening method was developed for detecting colonic stimulants in urine.
The method was applied over a three-year period, analyzing 157 samples from 81 patients.

Main Results:

Fifteen patients (18.5%) were confirmed to be using self-prescribed laxatives.

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Detected compounds included diphenolic laxatives (bisacodyl, phenolphthalein, bisoxatin) and anthraquinone derivatives (rhein, aloe-emodin).

Conclusions:

Chronic laxative self-poisoning is more prevalent than often assumed and can be easily missed.
Urine screening is an economical and reliable diagnostic tool for suspected cases of laxative abuse.