Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Homogeneously staining regions and tumorigenicity.

F Gilbert, G Balaban, D Brangman

    International Journal of Cancer
    |June 15, 1983
    PubMed
    Summary

    Homogeneously staining regions (HSRs), linked to gene amplification, grew larger as human retinoblastoma cells became more tumorigenic. This suggests HSR length correlates with cancer progression in vivo.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Observation of Single-Top-Quark Production in Association with a Photon Using the ATLAS Detector.

    Physical review letters·2023
    Same author

    Measurement of Suppression of Large-Radius Jets and Its Dependence on Substructure in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

    Physical review letters·2023
    Same author

    Measurement of the Sensitivity of Two-Particle Correlations in pp Collisions to the Presence of Hard Scatterings.

    Physical review letters·2023
    Same author

    Observation of the γγ→ττ Process in Pb+Pb Collisions and Constraints on the τ-Lepton Anomalous Magnetic Moment with the ATLAS Detector.

    Physical review letters·2023
    Same author

    Observation of an Excess of Dicharmonium Events in the Four-Muon Final State with the ATLAS Detector.

    Physical review letters·2023
    Same author

    Strong Constraints on Jet Quenching in Centrality-Dependent p+Pb Collisions at 5.02 TeV from ATLAS.

    Physical review letters·2023

    Area of Science:

    • Cytogenetics
    • Cancer Biology
    • Molecular Oncology

    Background:

    • Homogeneously staining regions (HSRs) are chromosome abnormalities.
    • HSRs are associated with gene amplification.
    • Retinoblastoma is a pediatric eye cancer.

    Purpose of the Study:

    • To investigate the relationship between HSRs and tumorigenicity.
    • To study the in vivo behavior of HSRs in retinoblastoma cells.

    Main Methods:

    • Serial passaging of human retinoblastoma cells in athymic mice.
    • Monitoring HSR length and tumorigenicity over passages.

    Main Results:

    • HSR length increased with serial passaging.
    • Tumorigenicity of the cells was enhanced with serial passaging.
    • HSR length correlated with increased tumorigenicity.

    Conclusions:

    • HSRs in retinoblastoma cells can increase in size.
    • Increased HSR size is associated with enhanced tumor-forming ability.
    • HSRs may play a role in retinoblastoma progression.

    Related Experiment Videos