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Regeneration of organized epithelial structure.
The Journal of Investigative Dermatology
|July 1, 1983
Summary
Adult epithelial growth requires specific dermal connective tissues. Experiments show these tissues, and factors they produce, are essential for normal epithelial structure and development.
Area of Science:
- Connective tissue biology
- Epithelial development
- Tissue engineering
Background:
- The role of connective tissue in adult epithelial maintenance and growth is not well understood.
- Mesenchyme is known to influence epithelial development in embryos and adults.
Purpose of the Study:
- To investigate the role of connective tissue in facilitating and directing adult epithelial growth.
- To identify specific connective tissue types and factors involved in epithelial development.
Main Methods:
- Review of existing literature on epithelial structure maintenance and mesenchymal roles.
- In vitro experiments on epithelial growth.
- In vivo transplantation experiments of epithelial and connective tissues.
Main Results:
- Dermal elements are required for reestablishing normal epithelial structure.
- Dermal, not deep, connective tissues facilitate adult epithelial growth in vivo.
- In vitro studies suggest diffusible factors produced by dermal tissues promote epithelial growth.
Conclusions:
- Specific dermal connective tissues are crucial for adult epithelial growth and development.
- Dermal factors play a significant role in facilitating epithelial proliferation.