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Related Experiment Videos

Routine laboratory determinations in pediatric allergic disease.

J A Church, W Richards

    Annals of Allergy
    |September 1, 1978
    PubMed
    Summary

    Elevated IgE or blood eosinophilia are common in children with atopic disease. These markers, along with nasal eosinophils, help diagnose conditions like asthma and allergies.

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    Area of Science:

    • Pediatric Allergy and Immunology
    • Clinical Laboratory Science

    Background:

    • Atopic diseases are prevalent in childhood, necessitating accurate diagnostic markers.
    • Understanding the utility of eosinophil counts and immunoglobulin E (IgE) levels is crucial for diagnosis.

    Purpose of the Study:

    • To evaluate the diagnostic value of blood eosinophilia and nasal eosinophil counts in children with suspected atopic disease.
    • To determine the prevalence of elevated total serum IgE and its correlation with specific atopic conditions.

    Main Methods:

    • Retrospective analysis of clinical and laboratory data from 285 children undergoing evaluation for atopic disease.
    • Assessment of blood eosinophil counts (complete blood count), nasal smear eosinophils, and total serum IgE levels.
    • Documentation of selective IgA deficiency and hyperimmunoglobulinemia.

    Main Results:

    • Blood eosinophilia was present in over 60% of tested children.
    • Elevated total serum IgE was found in 75-81% of children with asthma, nasal allergy, or atopic dermatitis.
    • Combined elevated IgE or blood eosinophilia was observed in 85% of patients; nasal eosinophil tests offered limited additional value.

    Conclusions:

    • Blood eosinophilia and elevated total serum IgE are significant indicators in diagnosing pediatric atopic diseases.
    • These laboratory findings, particularly when combined, demonstrate high sensitivity for atopic reactivity.
    • Nasal eosinophil assessments provided minimal incremental diagnostic information compared to blood tests.

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