[Method of gamma teletherapy in prostatic cancer]

Area of Science:

• Oncology
• Radiation Therapy

Context:

• Prostate cancer treatment requires precise radiation delivery.
• Accurate staging and dose planning are crucial for effective gamma-beam therapy.

Purpose:

• To develop and evaluate three variants of gamma-beam therapy for prostate cancer based on tumor dissemination.
• To optimize treatment strategies for different stages of prostate cancer, including localized and metastatic disease.

Summary:

• Three tailored gamma-beam therapy protocols were developed using detailed topometric preparation and computer-aided dose distribution analysis.
• Treatment strategies range from moving one- or two-field therapy for localized tumors to combined approaches with static cross irradiation and estrogen therapy for advanced stages involving lymph nodes.
• Specific dose regimens include 45-50 Gy for regional lymph nodes and 65-70 Gy for the primary tumor, with paraaortal lymph node irradiation at 30-40 Gy when indicated.

Impact:

• The study treated 69 patients with Stage II-IV prostate cancer.
• No severe reactions or late complications were observed within 6-36 months post-therapy.
• A 3-year survival rate exceeding 61% was achieved, indicating the efficacy and safety of the developed gamma-beam therapy variants.