[Effect of hyperbilirubinaemia on cerebellar development in Gunn rats]

The influence of bilirubin on cerebellar growth was studied in homozygous Gunn rats by measuring weight, DNA concentration and histochemical enzyme reactions at different ages and under different conditions. High bilirubin levels cause persistent reduction in cerebellar size and loss of Purkinje and granular cells. Sulfonamide application results in an almost complete cessation of cerebellar growth. Phototherapy can prevent these neurotoxic effects of bilirubin. The vulnerability of the cerebellum is particularly high during the period of rapid growth.