Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SCE, X-radiation sensitivity and mutation rate in multiple sclerosis.

R Seshadri, G R Sutherland, E Baker

    Mutation Research
    |June 1, 1983
    PubMed
    Summary

    Multiple sclerosis (MS) patients exhibited an increased sister chromatid exchange (SCE) rate, indicating potential DNA instability. However, their X-radiation sensitivity and 6-thioguanine-resistant cell frequency remained normal.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mixed-methods study protocol to develop and pilot a Competency Assessment Tool to support therapists in the care of patients with blunt CHest trauma (CATCh study).

    BMJ open·2025
    Same author

    Do variations in nasal irrigation recipes and storage effect the risk of bacterial contamination? - ERRATUM.

    The Journal of laryngology and otology·2023
    Same author

    Do variations in nasal irrigation recipes and storage effect the risk of bacterial contamination?

    The Journal of laryngology and otology·2022
    Same author

    European Society of Cardiology quality indicators for the prevention and management of cancer therapy-related cardiovascular toxicity in cancer treatment.

    European heart journal. Quality of care & clinical outcomes·2022
    Same author

    Hemorrhagic Transformation Rates following Contrast Media Administration in Patients Hospitalized with Ischemic Stroke.

    AJNR. American journal of neuroradiology·2022
    Same author

    Minimally invasive biomarkers to detect maternal physiological status in sow saliva and milk.

    Animal : an international journal of animal bioscience·2021

    Area of Science:

    • Genetics
    • Neurology
    • Molecular Biology

    Background:

    • Multiple sclerosis (MS) is a complex neurological disease with potential underlying genetic factors.
    • Investigating DNA abnormalities in MS patients is crucial for understanding disease mechanisms.

    Purpose of the Study:

    • To assess DNA damage and repair mechanisms in lymphocytes of multiple sclerosis patients.
    • To determine if increased sister chromatid exchange (SCE), X-radiation sensitivity, or 6-thioguanine-resistant cell frequency are associated with MS.

    Main Methods:

    • Lymphocytes from 34 MS patients and controls were analyzed.
    • Incidence of sister chromatid exchange (SCE) was quantified.
    • X-radiation sensitivity was assessed.
    • Frequency of 6-thioguanine-resistant mutant cells was determined.

    Related Experiment Videos

    Main Results:

    • MS patients demonstrated a significantly higher rate of sister chromatid exchange (SCE) compared to the control group.
    • No significant difference was observed in X-radiation sensitivity between MS patients and controls.
    • The frequency of 6-thioguanine-resistant mutant cells was comparable in both MS patients and controls.

    Conclusions:

    • Elevated SCE rates in MS patients suggest potential DNA instability or altered repair pathways.
    • X-radiation sensitivity and 6-thioguanine resistance do not appear to be primary indicators of DNA abnormality in MS.
    • Further research is needed to elucidate the specific DNA abnormalities contributing to multiple sclerosis pathogenesis.