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Related Experiment Videos

A transient component of the developing corticospinal tract arises in visual cortex.

C E Adams, G A Mihailoff, D J Woodward

    Neuroscience Letters
    |April 29, 1983
    PubMed
    Summary

    Early visual cortex connections to the spinal cord are transient. Axons present in the first postnatal week are lost later, suggesting developmental pruning of corticospinal pathways.

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    Area of Science:

    • Neuroscience
    • Developmental Neuroscience
    • Neuroanatomy

    Background:

    • The corticospinal tract is crucial for voluntary motor control.
    • The developmental trajectory and plasticity of corticospinal projections are not fully understood.
    • The role of early-postnatal visual cortex in forming descending motor pathways requires further investigation.

    Purpose of the Study:

    • To investigate the developmental course of corticofugal projections originating from the visual cortex.
    • To determine if early-formed visual-to-spinal cord connections are maintained into adulthood.
    • To elucidate the mechanisms underlying the potential elimination of these transient connections.

    Main Methods:

    • Injections of tritiated leucine into the visual cortex of rodents at specific early postnatal ages (days 3-6 and during the second postnatal week).

    Related Experiment Videos

  • Anterograde tracing of labeled corticofugal axons using autoradiography.
  • Analysis of axonal pathways and terminal fields at various rostrocaudal levels, including the pons, medullary pyramid, and cervical spinal cord.
  • Comparative analysis between early (first postnatal week) and later (second postnatal week) developmental stages, as well as adult animals.

    • Main Results:

    • Labeled corticofugal axons from the visual cortex were traced to the cervical spinal cord when injections were performed during the first postnatal week.
    • When injections were made during the second postnatal week, labeled axons terminated in the basilar pontine nuclei and could not be traced caudally beyond the mid-pons.
    • Axonal labeling did not persist at caudal levels in later developmental stages or in adults, indicating a loss of these projections.

    Conclusions:

    • The contribution of visual cortical axons to the corticospinal system during the first postnatal week is a transient connection.
    • This transient connection is likely eliminated through developmental processes such as selective axon collateral elimination or programmed cell death.
    • These findings highlight the dynamic nature of early neural circuit formation and refinement in the developing brain.