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Hypertrophic osteoarthropathy: two unusual causes.

P V Barber, R Lechler

    Postgraduate Medical Journal
    |April 1, 1983
    PubMed
    Summary

    Two patients presented with hypertrophic osteoarthropathy linked to rare causes: esophageal cancer and active pulmonary tuberculosis. The latter case showed significant bone resorption after treatment, highlighting potential therapeutic responses.

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    Area of Science:

    • Medicine
    • Oncology
    • Pulmonology

    Background:

    • Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by digital clubbing, arthritis, and subperiosteal new bone formation.
    • HOA typically occurs secondary to intrathoracic malignancy or chronic suppurative lung disease.
    • Unusual etiologies of HOA require further investigation to understand pathogenesis and management.

    Observation:

    • The first patient exhibited HOA associated with esophageal carcinoma.
    • The second patient developed HOA as a complication of active pulmonary tuberculosis.
    • The second case demonstrated substantial resorption of new bone following treatment for tuberculosis.

    Findings:

    • This report details two cases of hypertrophic osteoarthropathy with uncommon underlying causes.
    • Esophageal carcinoma and active pulmonary tuberculosis are identified as potential triggers for HOA.
    • Successful treatment of pulmonary tuberculosis led to significant bone resorption in a patient with HOA.

    Implications:

    • The findings suggest that HOA can arise from diverse and less common etiologies beyond typical associations.
    • Recognition of these unusual causes is crucial for accurate diagnosis and timely intervention.
    • The observed bone resorption in the tuberculosis case indicates potential reversibility of HOA manifestations with effective disease management.

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