[Brain tumors in the rat induced by methylnitrosourea (induction, transplantation, monolayer cultivation)]

Tumors induced in rats by chronic methylnitrosourea administration are described. Two strains of transplantable brain gliomas obtained by serial intracerebral transplantation of primary neoplasms and their monolayer cultures are characterized. These tumors were similar to human malignant gliomas in morphological and biological properties. They possesses high oncogenicity and are easily cultured in a monolayer, which allows their application in oncological and biochemical studies.