Neurotensin and antinatriuresis in the conscious rabbit

The mechanism of alteration in renal sodium excretion in response to dietary changes is complex and poorly understood. A gut 'sensor' might exist which regulates the renal response and this may involve one or more of the now ubiquitous gastrointestinal peptides. Several of these gut peptides, including neurotensin, have been found within the kidney. Plasma levels of neurotensin, which is both a circulating hormone and putative neurotransmitter, rise promptly on feeding. When infused into the conscious rabbit, neurotensin produces a dose-related fall in renal sodium excretion.