[Familial occurrence of basilar impression]

Area of Science:

• Neurology
• Genetics
• Neurosurgery

Context:

• Investigates a family with a history of neurological disorders.
• Focuses on basilar impression and Arnold-Chiari malformation within a familial context.

Purpose:

• To explore the potential hereditary nature of basilar impression and Arnold-Chiari malformation.
• To identify common clinical and radiological features in affected family members.

Summary:

• Nine family members were assessed, with two undergoing surgery for basilar impression and Arnold-Chiari malformation.
• Other family members exhibited signs of central nervous system disease.
• All patients presented with the odontoid apophysis apex above McGregor's line, indicating a shared anatomical abnormality.

Impact:

• Suggests a possible genetic predisposition to these complex neurological conditions.
• Highlights the importance of family history in diagnosing and managing basilar impression and Arnold-Chiari malformation.
• Provides radiological evidence supporting a familial link.