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On the interaction between digoxin and disopyramide.

T Risler, M Burk, U Peters

    Clinical Pharmacology and Therapeutics
    |August 1, 1983
    PubMed
    Summary
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    Combined oral therapy with digoxin and disopyramide did not affect steady-state digoxin levels. However, high-dose disopyramide significantly reduced digoxin

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Drug Interactions

    Background:

    • Digoxin is a cardiac glycoside used for heart failure and arrhythmias.
    • Disopyramide is an antiarrhythmic drug.
    • Potential drug interactions between digoxin and disopyramide require investigation.

    Purpose of the Study:

    • To evaluate the pharmacokinetic interaction between oral digoxin and oral disopyramide.
    • To assess the effect of disopyramide on digoxin serum concentrations and clearance.

    Main Methods:

    • Nine subjects received combined oral therapy with digoxin and disopyramide (300 and 600 mg/day).
    • Steady-state digoxin serum concentrations were measured.
    • Digoxin and creatinine clearances were determined.

    Related Experiment Videos

  • Pharmacokinetic parameters of digoxin after IV bolus dose were assessed with and without disopyramide.

    • Main Results:

    • Combined therapy did not alter steady-state digoxin serum concentrations or clearances.
    • After 600 mg oral disopyramide, the volume of distribution and elimination half-life of digoxin were significantly reduced.
    • Total clearance and distribution half-life of digoxin remained unchanged.

    Conclusions:

    • High-dose oral disopyramide may alter digoxin distribution and elimination.
    • The clinical significance of this digoxin-disopyramide interaction is currently unclear and warrants further study.