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[Veno-occlusive disease of the liver. Treatment by portocaval shunt]

H Lamouliatte, A Quinton, D Plane

    Gastroenterologie Clinique Et Biologique
    |April 1, 1983
    PubMed

    Insights

    Medicinal plant use for weight loss can cause hepatic veno-occlusive disease (HVOD), characterized by ascites. Surgical intervention, a side-to-side portacaval shunt, effectively resolved symptoms and improved liver fibrosis.

    Area of Science:

    • Hepatology
    • Toxicology

    Background:

    • Hepatic veno-occlusive disease (HVOD) is a serious liver condition.
    • It can be caused by various toxins, including certain medicinal plants.

    Observation:

    • A 33-year-old French female presented with abdominal pain and rapid ascites development.
    • She had consumed medicinal plants for weight loss, suggesting a potential etiological link.

    Findings:

    • Liver biopsy confirmed HVOD with centrizonal hemorrhagic necrosis and centrolobular vein obstruction.
    • A side-to-side portacaval shunt was performed due to worsening ascites.
    • Post-shunt, ascites resolved, and follow-up biopsies showed reduced liver fibrosis.

    Implications:

    • This case highlights the potential hepatotoxicity of weight-loss herbal remedies.
    • Portacaval shunting can be an effective treatment for refractory ascites in HVOD.
    • Early diagnosis and intervention are crucial for managing HVOD and improving patient outcomes.

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