Ocular tumors react with anti-neuroblastoma monoclonal antibodies

The reactivities of mouse monoclonal antibodies directed against human neuroblastoma and peripheral melanoma associated antigens, with human retinoblastoma and choroidal melanoma cell lines were tested. Segregation of antigenic determinants according to each tumor class and cell line were observed. Three retinoblastoma cell lines and one fresh tumor explant showed determinants detected by two human neuroblastoma antisera, while the choroidal melanoma showed one determinant present on a peripheral melanoma but not neuroblastomas nor retinoblastomas, suggesting certain potential distinctive tumor related determinants.