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Pulmonary denervation in the dog.

P S Clifford, R L Coon, J H von Colditz

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |June 1, 1983
    PubMed
    Summary
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    Researchers created a lung-denervated animal model in dogs by surgically severing vagal nerves. While effective initially, the Hering-Breuer reflex (HBR) returned within weeks, indicating reinnervation.

    Area of Science:

    • Veterinary Surgery
    • Pulmonary Physiology
    • Animal Models

    Background:

    • Creating animal models for studying lung denervation is crucial for physiological research.
    • The Hering-Breuer reflex (HBR) is a key indicator of pulmonary vagal nerve function.

    Purpose of the Study:

    • To develop a surgical method for creating a chronically lung-denervated animal model in beagle dogs.
    • To assess the duration and efficacy of pulmonary denervation using the Hering-Breuer reflex (HBR) as a criterion.

    Main Methods:

    • A single-stage surgical procedure involving left thoracotomy, hilar stripping of pulmonary vagal nerves, and right vagal trunk transection was performed on five beagle dogs.
    • The Hering-Breuer reflex (HBR) was evaluated in denervated dogs (DD) and control dogs (CD) under anesthesia.

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  • Absence of the HBR was the criterion for successful denervation.

    • Main Results:

    • The Hering-Breuer reflex (HBR) was abolished in denervated dogs (DD) between 3 and 8 weeks post-surgery.
    • The HBR remained present in control dogs (CD) throughout the study period.
    • Reinnervation, indicated by the return of the HBR, was observed in denervated dogs (DD) by 12-14 weeks post-surgery.

    Conclusions:

    • The described surgical procedure effectively creates a temporary lung-denervated animal model.
    • Pulmonary reinnervation occurs relatively quickly after surgical denervation.
    • Regular and frequent evaluation of the Hering-Breuer reflex (HBR) is essential when utilizing this model.