Related Experiment Video

Updated: Aug 12, 2026

In Vitro Differentiation of Mature Myofibers for Live Imaging
08:12

In Vitro Differentiation of Mature Myofibers for Live Imaging

Published on: January 7, 2017

Switching of subunit composition of muscle spectrin during myogenesis in vitro

W J Nelson, E Lazarides

    Nature
    |July 3, 1983
    PubMed

    More Related Videos

    Studying Muscle Transcriptional Dynamics at Single-molecule Scales in Drosophila10:22

    Studying Muscle Transcriptional Dynamics at Single-molecule Scales in Drosophila

    Published on: September 8, 2023

    Intact Short, Intermediate, and Long Skeletal Muscle Fibers Obtained by Enzymatic Dissociation of Six Hindlimb Muscles of Mice: Beyond Flexor Digitorum Brevis08:12

    Intact Short, Intermediate, and Long Skeletal Muscle Fibers Obtained by Enzymatic Dissociation of Six Hindlimb Muscles of Mice: Beyond Flexor Digitorum Brevis

    Published on: December 1, 2023

    Related Concept Videos

    Classification of Skeletal Muscle Fibers01:48

    Classification of Skeletal Muscle Fibers

    Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
    Slow-Twitch Muscle Fibers
    Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
    Actin and Myosin in Muscle Contraction01:16

    Actin and Myosin in Muscle Contraction

    Actin and myosin are contractile proteins that form the sarcomere found in skeletal muscle tissues for regulating muscle contraction. Actin, a globular contractile protein, interacts with myosin for muscle contraction. The skeletal tissue appears striped or striated under a microscope due to the repeated arrangement of contractile proteins actin and myosin along the length of myofibrils. Dark A bands and light I bands repeat along myofibrils, and the alignment of myofibrils in the cell causes...
    Formation of Muscle Fibers from Myoblasts01:13

    Formation of Muscle Fibers from Myoblasts

    De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
    Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...
    Microscopic Anatomy of Skeletal Muscles01:13

    Microscopic Anatomy of Skeletal Muscles

    Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
    The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...
    The Sarcomere01:08

    The Sarcomere

    A sarcomere is a microscopic segment repeating in a myofibril. The sarcomere fundamentally consists of two main myofilaments: thick filaments called myosin and thin filaments called actin. These filaments interact by sliding past each other in response to stimulus. In addition to myosin and actin, several other proteins, such as tropomyosin, troponin, titin, nebulin, myomesin, α-actinin, and dystrophin, play crucial roles in regulating, structuring, and functioning of the sarcomere.
    Each myosin...