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Pyrethroid effects on operant responding and feeding.

A S Bloom, C G Staatz, T Dieringer

    Neurobehavioral Toxicology and Teratology
    |May 1, 1983
    PubMed
    Summary
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    Pyrethroid insecticides like permethrin and deltamethrin significantly impair learned behaviors and reduce food intake in rats, even at subconvulsive doses. These findings highlight potential neurotoxic effects of common pesticides.

    Area of Science:

    • Toxicology
    • Neuroscience
    • Behavioral Pharmacology

    Background:

    • Pyrethroids are widely used insecticides.
    • Concerns exist regarding their neurotoxic effects on mammals.
    • Understanding behavioral impacts is crucial for risk assessment.

    Purpose of the Study:

    • To investigate the effects of permethrin, its isomers, and deltamethrin on operant behavior and food intake in rats.
    • To determine dose-response relationships for these pyrethroids.
    • To assess the impact of subconvulsive doses on learned behaviors.

    Main Methods:

    • Male Sprague-Dawley rats were trained on a variable interval schedule of reinforcement.
    • Rats received intraperitoneal injections of pyrethroids or vehicle.

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  • Operant response rates and food intake were measured post-injection.

    • Main Results:

    • Technical permethrin caused a dose-related decrease in operant response rates.
    • Doses of 60 mg/kg permethrin reduced response rates by 60%.
    • Cis-permethrin and deltamethrin also significantly decreased response rates; trans-permethrin had no effect.
    • High-dose permethrin reduced food intake over 1.5 and 24-hour periods.

    Conclusions:

    • Subconvulsive doses of pyrethroid insecticides can significantly affect learned behavior.
    • Pyrethroids demonstrably impact food intake.
    • These findings suggest potential neurotoxic mechanisms of action for pyrethroids in mammals.