Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemoglobin solutions as a blood substitute.

R Bolin, F DeVenuto

    Progress in Clinical and Biological Research
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Developing hemoglobin (Hb)-based oxygen carriers for human use requires addressing key challenges. Research focuses on physiological criteria, chemical modifications, efficacy in animal models, and ensuring safety for clinical applications.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Shelter, housing and recovery: a comparison of u.s. Disasters.

    Disasters·2010
    Same author

    Purification and characterization of YACs containing large inserts.

    Current protocols in human genetics·2008
    Same author

    Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys.

    Pharmaceutical research·2001
    Same author

    Hemoglobin solutions as blood substitutes.

    Journal of investigative surgery : the official journal of the Academy of Surgical Research·2000
    Same author

    The Northridge earthquake: community-based approaches to unmet recovery needs.

    Disasters·1998
    Same author

    YAC contigs covering an 8-megabase region of 3p deleted in the small-cell lung cancer cell line U2020.

    Genomics·1995

    Area of Science:

    • Biomedical Engineering
    • Hematology
    • Translational Medicine

    Background:

    • Hemoglobin (Hb)-based oxygen-transporting solutions are being developed as potential blood substitutes.
    • Significant hurdles remain before these solutions can be approved for human clinical use.

    Purpose of the Study:

    • To outline the critical considerations for the development of Hb-derived oxygen carriers.
    • To define the essential steps required to advance these products toward human application.

    Main Methods:

    • Physiological assessment of oxygen-transporting Hb properties for optimal tissue oxygenation.
    • Characterization of chemical modifications to the Hb molecule and its environment.
    • Evaluation of product efficacy in relevant animal models simulating clinical scenarios.

    Related Experiment Videos

  • Establishment of safety profiles for intended human use.

    • Main Results:

    • Four fundamental issues must be systematically addressed: physiological criteria, chemical characterization, preclinical efficacy, and safety validation.
    • Successful navigation of these issues is paramount for the successful translation of Hb-based oxygen carriers.

    Conclusions:

    • A rigorous, multi-faceted approach is necessary to ensure the viability and safety of Hb-derived oxygen carriers for human transfusion.
    • Addressing these core challenges will pave the way for the clinical application of these innovative oxygen-transporting solutions.