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Neohemocytes.

C A Hunt, R R Burnette

    Progress in Clinical and Biological Research
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Neohemocytes, artificial red blood cells, significantly increase survival time in rats compared to unencapsulated hemoglobin. These microcapsules show promise as a resuscitative fluid for human use.

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    Area of Science:

    • Biomaterials Science
    • Hematology
    • Resuscitative Medicine

    Background:

    • Artificial oxygen carriers are crucial for medical emergencies.
    • Microencapsulation of hemoglobin presents challenges in stability and efficacy.
    • Neohemocytes offer a potential solution to these challenges.

    Purpose of the Study:

    • To characterize neohemocytes, a novel hemoglobin-based oxygen carrier.
    • To evaluate the efficacy of neohemocytes in a preclinical model.
    • To assess the potential of neohemocytes as a resuscitative fluid.

    Main Methods:

    • Characterization of neohemocyte size, membrane composition (biodegradable lipids, phospholipids), and suspension volume.
    • Measurement of encapsulated hemoglobin concentration, P50, Hill Number, and methemoglobin levels.

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  • In vivo transfusion studies in rats with compromised red blood cell hematocrit.

    • Main Results:

    • Neohemocytes average 0.4 microns in diameter with a liposome-like structure.
    • Encapsulated hemoglobin averaged 15.8g%, with favorable oxygen-binding properties (P50=26, Hill Number=2.1) and low methemoglobin (<5%).
    • Transfusions of neohemocytes in rats resulted in a fivefold increase in survival time compared to unencapsulated hemoglobin.

    Conclusions:

    • Neohemocyte technology has overcome previous microencapsulation challenges.
    • Neohemocytes demonstrate superior efficacy as an oxygen carrier in vivo.
    • Neohemocytes show significant potential as a component of a human resuscitative fluid.