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Hypernatremia with choroid plexus hematomas and elevated CSF protein level.

E S Roach, J N Angelo, R J Boyle

    Southern Medical Journal
    |August 1, 1983
    PubMed
    Summary
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    A 3-month-old infant with hypernatremia experienced severe neurologic issues and elevated cerebrospinal fluid (CSF) protein. Autopsy revealed choroid plexus destruction and coagulation, explaining the extreme CSF protein levels.

    Area of Science:

    • Pediatric Neurology
    • Pathology
    • Biochemistry

    Background:

    • Hypernatremia in infants can lead to serious neurological complications.
    • Elevated cerebrospinal fluid (CSF) protein is a known indicator of central nervous system inflammation or damage.

    Observation:

    • A 3-month-old infant presented with hypernatremia, neurological dysfunction, and markedly elevated CSF protein.
    • Autopsy revealed cerebral edema, intravascular coagulation, and bilateral choroid plexus hematomas.

    Findings:

    • Extensive destruction of the choroid plexus was observed.
    • Diffuse intravascular coagulation was present throughout the brain.

    Implications:

    • The combination of choroid plexus destruction and intravascular coagulation likely accounts for the unprecedented elevation in CSF protein seen in this case.

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  • This case highlights a potential mechanism for severe CSF protein elevation in infant hypernatremia, informing diagnostic and prognostic considerations.