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Solubility effects on corneal oxygen measurement.

T G Quinn, J P Schoessler

American Journal of Optometry and Physiological Optics

|May 1, 1983

Summary

Different membrane materials significantly impact corneal oxygen uptake measurements. New solubility constants were derived for polyethylene, Teflon, and polypropylene, improving accuracy for oxygen sensor data.

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Area of Science:

Ophthalmology
Biomedical Engineering
Materials Science

Background:

Accurate measurement of corneal oxygen uptake is crucial for understanding ocular physiology and contact lens performance.
Various membrane materials are used with oxygen sensors, but their differing solubility characteristics can introduce variability in flux measurements.
Previous studies relied on hydrophilic lens membranes, necessitating a recalibration for other common materials.

Purpose of the Study:

To investigate the effect of different membrane materials (polyethylene, Teflon, polypropylene) on corneal oxygen uptake measurements.
To develop conversion coefficients to standardize oxygen uptake data obtained with various membrane-sensor systems.
To derive new solubility constants for commonly used membrane materials.

Main Methods:

Human corneal epithelial oxygen uptake was measured using an oxygen sensor.
The oxygen sensor was equipped with polyethylene, Teflon, and polypropylene membranes.
Conversion coefficients were calculated, and new solubility constants were derived using prior data from a saline membrane reservoir.

Main Results:

The choice of membrane material significantly influences measured corneal oxygen flux values.
Calculated conversion coefficients allow for the standardization of data across different membrane-sensor configurations.
New solubility constants for polyethylene, Teflon, and polypropylene were successfully derived.

Conclusions:

Membrane material selection is a critical factor in the accuracy of corneal oxygen uptake measurements.
The derived conversion coefficients and solubility constants provide a method to reconcile data obtained with different membrane materials.
This work enhances the reliability and comparability of oxygen sensor data in ocular research.

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