Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA sharing in multiplex sibships.

B K Suarez, J Crouse, P Van Eerdewegh

    Annals of Human Genetics
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    This study derives the proportion of affected siblings sharing marker haplotypes identical by descent. Findings indicate this proportion depends on disease transmission, sibship size, and affected individuals, cautioning against inferring multiple disease loci from haplotype sharing alone.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The photoexcitation of crystalline ice and amorphous solid water: A molecular dynamics study of outcomes at 11 K and 125 K.

    The Journal of chemical physics·2015
    Same author

    Meta-analysis of 32 genome-wide linkage studies of schizophrenia.

    Molecular psychiatry·2009
    Same author

    TGFBR1*6A is not associated with prostate cancer in men of European ancestry.

    Prostate cancer and prostatic diseases·2004
    Same author

    Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma.

    Thorax·2003
    Same author

    Identification of a gene frequently mutated in prostate tumors.

    Medical oncology (Northwood, London, England)·2002
    Same author

    A kinship analysis of asthma among the Hutterites.

    Genetic epidemiology·2002
    Same journal

    FIGLA Novel Variant c.385-9G>A Affects RNA Splicing in a Minigene Assay.

    Annals of human genetics·2026
    Same journal

    Epigenetic Shifts in MTNR1A, MTNR1B and Fn14 and Their Links to Preeclampsia Risk.

    Annals of human genetics·2026
    Same journal

    Hip Bone Marrow Adiposity as a Risk Factor for Alzheimer's Disease: Insights From Mendelian Randomization Analysis.

    Annals of human genetics·2026
    Same journal

    A Novel Biallelic REL Frameshift Variant p.(Tyr9Ilefs*2) Causing Immunodeficiency-92 With Profound c-Rel Deficiency.

    Annals of human genetics·2026
    Same journal

    Identification of PSMA4 as a Therapeutic Target for Atherosclerosis: A Comprehensive Multiomics Mendelian Randomization Analysis.

    Annals of human genetics·2026
    Same journal

    Genetic Insights Into Hypertension and Breast Cancer Risk in African Women: A Mendelian Randomization and Colocalization Analyses.

    Annals of human genetics·2026
    See all related articles

    Area of Science:

    • Genetics
    • Biostatistics
    • Epidemiology

    Background:

    • Understanding genetic inheritance patterns is crucial for identifying disease susceptibility loci.
    • Sibling studies are a common approach in genetic epidemiology to investigate familial disease aggregation.

    Purpose of the Study:

    • To derive the proportion of affected siblings sharing marker haplotypes identical by descent.
    • To investigate the factors influencing this proportion within a generalized single locus model.

    Main Methods:

    • Mathematical derivation of haplotype sharing proportions.
    • Analysis of a generalized single locus disease transmission model.
    • Examination of sibship size and number of affected individuals as parameters.

    Related Experiment Videos

    Main Results:

    • The proportion of affected siblings sharing both marker haplotypes identical by descent is mathematically derived.
    • This proportion is dependent on disease transmission parameters, total sibship size, and the number of affected siblings.

    Conclusions:

    • Observed patterns of identity by descent can be complex and influenced by multiple factors.
    • Inferring additional independent disease susceptibility loci solely based on the inverse relationship between haplotype sharing and the number of affected siblings may lead to inaccurate conclusions.