Brain maturation and types of perinatal hypoxic-ischemic encephalopathy

The degree of brain maturation and the location of hemorrhage in the germinal layer and of periventricular leukomalacia were analyzed in 85 newborn brains. The average age of the premature brains with hemorrhage was 31 weeks and of those with leukomalacia 37 weeks. Hemorrhage was more frequently found in the frontal regions, while periventricular leukomalacia predominated in the parieto-occipital regions. This study confirms that the type and the location of the hypoxic-ischemic perinatal cerebral damage are dependent on the rate of regression of the embryonic type of periventricular arterial vascularization in the premature brain.