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Related Experiment Videos

Immunological recovery after measles.

A Wesley, H M Coovadia, L Henderson

    Clinical and Experimental Immunology
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Measles infection significantly lowers lymphocyte counts and impairs T-cell function in children, with deficits persisting for six weeks. Immune system recovery shows a gradual increase in immunoglobulin G, immunoglobulin M, and complement factors.

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    Area of Science:

    • Immunology
    • Pediatrics
    • Infectious Diseases

    Background:

    • Measles is a highly contagious viral illness.
    • Immune system dysregulation is a known complication of measles.
    • Understanding the specific immunological impact of measles is crucial for patient management.

    Purpose of the Study:

    • To investigate the effects of measles on lymphocyte counts and function in children.
    • To compare immune parameters in children with measles to healthy controls.
    • To track the duration of immunological changes post-measles infection.

    Main Methods:

    • Studied 22 children with measles during the rash phase and 6 weeks later.
    • Compared lymphocyte subpopulations (T-cells, B-cells, null cells) with matched controls.

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  • Assessed T-cell function via 14C uptake and delayed skin hypersensitivity.
  • Measured serum IgG, IgM, and complement factors.

    • Main Results:

    • Significantly lower total lymphocyte and subpopulation counts in measles patients compared to controls during the acute phase.
    • Persistently diminished B-cell and null-cell counts at 6 weeks post-infection.
    • Impaired T-cell function and delayed skin hypersensitivity observed during the acute phase, lasting for 6 weeks.
    • A small but significant increase in serum IgG, IgM, and complement factors over the 6-week study period.

    Conclusions:

    • Measles infection causes significant, albeit temporary, lymphopenia and T-cell dysfunction in children.
    • Immune recovery is gradual, with some lymphocyte populations remaining depressed for at least 6 weeks.
    • The study highlights the profound impact of measles on the pediatric immune system.