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A fatal chlordane poisoning.

F W Kutz, S C Strassman, J F Sperling

    Journal of Toxicology. Clinical Toxicology
    |April 1, 1983
    PubMed
    Summary
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    This study presents a fatal case of chlordane poisoning, detailing residue levels in human tissues. Highest chlordane concentrations were found in the stomach, liver, brain, and adipose tissue following ingestion.

    Area of Science:

    • Environmental Toxicology
    • Forensic Chemistry
    • Human Health Risk Assessment

    Background:

    • Chlordane, a widely used organochlorine insecticide, was prevalent in household and agricultural applications before EPA regulatory action in 1976.
    • Extensive public availability led to documented human exposure and poisonings.
    • Understanding chlordane's toxicokinetics and tissue distribution is crucial for assessing health risks.

    Observation:

    • A case of fatal chlordane ingestion is reported.
    • Gas-liquid chromatography was employed for residue analysis in various body tissues.
    • Significant chlordane residues were detected post-mortem.

    Findings:

    • Highest chlordane residue levels were quantified in stomach contents.
    • Elevated concentrations were also observed in the liver, brain, and adipose tissue.

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  • Tissue distribution indicates preferential accumulation in certain organs and fat stores.

    • Implications:

    • This case highlights the severe toxicity of chlordane and its potential to cause fatal poisoning.
    • Findings underscore the importance of monitoring and managing persistent organic pollutants in the environment and human tissues.
    • The data provides valuable insights into chlordane's distribution in the human body for forensic and toxicological investigations.