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An HPLC method for analysis of clonazepam in serum

W Shaw, G Long, J McHan

Journal of Analytical Toxicology

|May 1, 1983

Abstract:

A sensitive, accurate, and precise method for the analysis of clonazepam in serum was developed. The drug and internal standard from serum extracts were methylated to obviate carbamazepine interference and then resolved on a 5 micron C18 HPLC column. The mobile phase could also be used for many other basic drugs.

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