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Large delayed plasma creatine kinase changes after stepping exercise.

D J Newham, D A Jones, R H Edwards

    Muscle & Nerve
    |June 1, 1983
    PubMed
    Summary
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    Eccentric exercise, like stepping, can cause muscle damage and delayed enzyme release in some individuals. This muscle damage is linked to specific muscle lengthening contractions and can lead to prolonged recovery.

    Area of Science:

    • Exercise Physiology
    • Sports Medicine
    • Muscle Biology

    Background:

    • Eccentric contractions, involving muscle lengthening during activity, are a key component of stepping exercises.
    • The physiological responses to eccentric exercise, particularly delayed muscle damage and enzyme release, require further investigation.

    Purpose of the Study:

    • To investigate muscle damage and recovery following stepping exercise, focusing on eccentric contractions.
    • To identify factors contributing to delayed and elevated release of muscle enzymes after exercise.

    Main Methods:

    • 16 healthy subjects (8 female) performed 20-minute and prolonged step tests.
    • Measurements included plasma creatine kinase (CK) levels, muscle force, contractile properties, and tenderness.
    • Data were collected for up to 9 days post-exercise.

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    Main Results:

    • Muscle tenderness was localized to muscles performing eccentric contractions (stepping down).
    • All subjects exhibited an initial rise in CK (<400 IU/L).
    • Eight subjects showed a significant delayed CK increase (up to 34,500 IU/L) peaking 4-5 days post-exercise.

    Conclusions:

    • Eccentric contractions in stepping exercise can induce a unique form of muscle damage.
    • Susceptible individuals may experience a substantial, delayed release of muscle enzymes.
    • This suggests specific muscle damage mechanisms are activated by eccentric exercise.