Intravenous administration of sulpiride and heat sensation on the body surface

Sulpiride was administered intravenously to 19 patients in a depressive or hallucinatory-paranoid state. The sensation of heat appeared characteristic as a side-effect of intravenous sulpiride when viewed in terms of frequency (arising in 13 of 19 cases), the site of occurrence (symmetrical, often on the ventral side in the upper half of the body), and the mode of occurrence (changes in the site in a short period of time). The fact that the mechanism of this heat sensation remains obscure makes caution advisable in using the drug.