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Experimental infection with Basidiobolus haptosporus
Abstract:
The authors tried to reproduce experimentally the Basidiobolus haptosporus infection. Culture forms of the fungus were inoculated in 26 adult hamsters, in two newborn hamsters and in two marmosets. Oral, intratesticular, intrahepatic, intraperitonial and subcutaneous inoculations were made. Bethametasone was given prior to inoculation in a group of animals. The lesions produced were only of the foreign body type and there was no development of the fungus in the animal tissues. The AA concluded that an experimental model for the B. haptosporus infection has not yet been found.
Insights
Researchers attempted to experimentally induce Basidiobolus haptosporus infection in hamsters and marmosets. The study found no successful fungal development, concluding an effective experimental model for B. haptosporus infection is still lacking.
Area of Science:
- Mycology
- Veterinary Pathology
- Infectious Diseases
Background:
- Basidiobolus haptosporus is a fungus known to cause infections.
- Establishing reliable experimental models is crucial for studying fungal pathogenesis and developing treatments.
Purpose of the Study:
- To experimentally reproduce Basidiobolus haptosporus infection in animal models.
- To evaluate the efficacy of different inoculation routes and corticosteroid administration in infection development.
Main Methods:
- Inoculation of culture forms of Basidiobolus haptosporus into hamsters and marmosets.
- Utilized various routes: oral, intratesticular, intrahepatic, intraperitoneal, and subcutaneous.
- Administered betamethasone prior to inoculation in a subset of animals.
Main Results:
- Lesions observed were exclusively of the foreign body type.
- No evidence of Basidiobolus haptosporus fungal development within animal tissues was detected.
- Experimental infection was not successfully established across all tested animal models and inoculation methods.
Conclusions:
- The study failed to establish a viable experimental model for Basidiobolus haptosporus infection.
- Further research is needed to develop effective animal models for studying this fungal infection.