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Immunostimulating substances from human casein.

P Jollès, F Parker, F Floc'h

    Journal of Immunopharmacology
    |January 1, 1981
    PubMed
    Summary
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    Human casein peptides, derived from enzymatic digestion and Sephadex G-50 fractionation, show significant immunomodulating activity. Specific peptide fractions within a defined molecular weight range stimulate immune responses in vitro.

    Area of Science:

    • Biochemistry
    • Immunology
    • Food Science

    Background:

    • Casein, a major milk protein, is a source of bioactive peptides.
    • Understanding the immunomodulatory potential of casein-derived peptides is crucial for nutritional and therapeutic applications.

    Purpose of the Study:

    • To isolate and characterize immunomodulating peptide fractions from delipidated human casein.
    • To evaluate the in vitro immunomodulatory activity of these peptide fractions.

    Main Methods:

    • Delipidated human casein was enzymatically digested using trypsin.
    • The resulting peptide digest was fractionated using Sephadex G-50 chromatography.
    • Peptidic fractions were tested for immunomodulating activity in two in vitro models.

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    Main Results:

    • Fractionation yielded peptide fractions with varying molecular weights.
    • Fractions with molecular weights around 2,000 +/- 600 Daltons exhibited significant stimulating activity.
    • This activity was observed in the established in vitro immunomodulation models.

    Conclusions:

    • Enzymatically derived casein peptides possess inherent immunomodulatory properties.
    • Specific molecular weight ranges of casein peptides are associated with enhanced immune stimulation.
    • These findings support the potential use of casein-derived peptides as functional food ingredients or therapeutic agents.