Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Baroreceptor-induced decrease in muscle blood flow upon propranolol administration.

B Lisander, H Nilsson

    European Journal of Pharmacology
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Observations of a Solar Energetic Particle Event From Inside and Outside the Coma of Comet 67P.

    Journal of geophysical research. Space physics·2023
    Same author

    BepiColombo mission confirms stagnation region of Venus and reveals its large extent.

    Nature communications·2022
    Same author

    Inner southern magnetosphere observation of Mercury via SERENA ion sensors in BepiColombo mission.

    Nature communications·2022
    Same author

    Correction: Risk of hernia formation after radical prostatectomy: a comparison between open and robot-assisted laparoscopic radical prostatectomy within the prospectively controlled LAPPRO trial.

    Hernia : the journal of hernias and abdominal wall surgery·2022
    Same author

    SERENA: Particle Instrument Suite for Determining the Sun-Mercury Interaction from BepiColombo.

    Space science reviews·2021
    Same author

    Patient-reported chronic pain after open inguinal hernia repair with lightweight or heavyweight mesh: a prospective, patient-reported outcomes study.

    The British journal of surgery·2020
    Same journal

    Astaxanthin inhibits platelet-mediated thrombosis via suppression of bidirectional αIIbβ3 signaling.

    European journal of pharmacology·2026
    Same journal

    Repurposing of alogliptin to mitigate experimentally-induced ulcerative colitis and its associated pulmonary injury in rats through regulating inflammatory, necroptotic, and ER stress pathways.

    European journal of pharmacology·2026
    Same journal

    Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis.

    European journal of pharmacology·2026
    Same journal

    4-Octyl itaconate attenuates renal calculi formation by inhibiting ferroptosis and oxidative stress via the Nrf2-HO-1/SLC7A11 axis.

    European journal of pharmacology·2026
    Same journal

    VER155008 rescues cognitive impairment in P301S tauopathy mice by promoting HSPA8-mediated lipophagy.

    European journal of pharmacology·2026
    Same journal

    Okanin alleviates osteoarthritis by suppressing oxidative stress and pyroptosis via Nrf2/HO-1 activation.

    European journal of pharmacology·2026
    See all related articles

    Propranolol initially increases total peripheral resistance through a reflex mechanism involving baroreceptors. This effect on blood pressure regulation was observed in vagotomized cats, highlighting the role of baroreceptor reflexes.

    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology

    Background:

    • Propranolol is a beta-blocker with known cardiovascular effects.
    • The role of baroreceptors in mediating propranolol's acute effects on peripheral resistance is not fully understood.

    Purpose of the Study:

    • To investigate the acute effects of propranolol on vascular resistance.
    • To determine if baroreceptor reflexes mediate propranolol-induced changes in peripheral resistance.

    Main Methods:

    • Experiments were conducted on chloralosed, vagotomized cats.
    • Calf muscles were vascularly isolated but innervated and perfused.
    • Carotid baroreceptors were either exposed to ambient arterial pressure or perfused at constant pressure.

    Main Results:

    Related Experiment Videos

  • Propranolol administration led to a decrease in heart rate and an increase in isolated muscle bed resistance when baroreceptors were exposed to ambient pressure.
  • No increase in muscle flow resistance was observed when carotid sinuses were perfused at constant pressure, suggesting a reflex mechanism.

    • Conclusions:

    • The initial increase in total peripheral resistance following propranolol administration may be reflexly induced.
    • Baroreceptor activation plays a crucial role in mediating the acute cardiovascular responses to propranolol.