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Analysis of a monofluorinated analogue of amphetamine in brain tissue using gas chromatography with electron-capture

W A Cristofoli, G B Baker, R T Coutts

Progress in Neuro-Psychopharmacology & Biological Psychiatry

|January 1, 1982

Abstract:

1. Difficulties encountered in the analysis of the monofluorinated amphetamine, 2-amino-3-fluoro-1-phenylpropane (AFP), are discussed. 2. A novel assay procedure and its application to the analysis of AFP in the rat brain are described. The procedure involves pentafluorobenzoylation of AFP under aqueous conditions and quantitation by a gas chromatography equipped with a capillary column and an electron-capture detector.

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