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Nodular pulmonary amyloidosis. Description of a case with ultrastructure
Archives of Pathology & Laboratory Medicine
|February 1, 1980
Abstract:
A 64-year-old man with a suspicious asymptomatic coin lesion received a thoracotomy that showed two foci of isolated nodular pulmonary amyloidosis. Ultrastructural analysis verified the amyloid nature of the lesion and suggested that the fibrils were produced by plasma cells and processed by macrophages. The pathogenesis of this lesion is discussed in light of recent studies.
Insights
This study reports a rare case of isolated nodular pulmonary amyloidosis in a 64-year-old man. Ultrastructural analysis indicated plasma cells produced the amyloid fibrils, which were then processed by macrophages.
Area of Science:
- Pulmonary Medicine
- Pathology
- Cell Biology
Background:
- Pulmonary amyloidosis is a rare condition characterized by the deposition of amyloid protein in the lungs.
- Isolated nodular pulmonary amyloidosis is an uncommon subtype, often presenting as asymptomatic coin lesions.
- Understanding the cellular origins and processing of amyloid deposits is crucial for elucidating disease pathogenesis.