Multiple cutaneous carcinomas and lymphomas of the skin

There is an increased risk of malignancy (particularly skin carcinomas and malignant lymphomas) in patients who have genetically determined and acquired immunosuppression. Multiple cutaneous squamous and basal cell carcinomas of the face and scalp with adjacent lymphomatous infiltration of the skin developed in a patient with stage IVA diffuse poorly differentiated lymphocytic lymphoma. He had had one cycle of vincristine sulfate, prednisone, and cyclophosphamide therapy for his lymphoma more than one year before. He showed impaired delayed hypersensitivity response on skin testing with common antigens and he had a low serum (IgG) level.