[DNA-repair of lymphocytes during PUVA-treatment (author's transl)]

In 20 psoriatic patients under PUVA maintenance treatment blood samples had been collected imediately before and after the UVA irradiation. The DNA-repair activity has been determined in the isolated lymphocytes by the incorporation of 3H-thymidine during the first 3 h (inhibition of the semiconservative replication by hydroxyurea). There is evidence for an increased repair activity in the lymphocytes after PUVA treatment whereas the lymphocytes exposed only to 8-MOP (before UVA irradiation) show lower values. The difference is statistically significant 45 and 90 min after irradiation, but not any more after 3 h.