Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Respiratory depression after intrathecal narcotics.

G K Davies, C L Tolhurst-Cleaver, T L James

    Anaesthesia
    |November 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Three-dimensional RNA structure-based drug discovery.

    Journal of biomolecular structure & dynamics·2012
    Same author

    Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress.

    Neurochemistry international·2008
    Same author

    Photoluminescent characterization of atomic diffusion in core-shell nanoparticles.

    Optics express·2008
    Same author

    NMR determination of oligonucleotide structure.

    Current protocols in nucleic acid chemistry·2008
    Same author

    Troponin I, laboratory issues, and clinical outcomes in a district general hospital: crossover study with "traditional" markers of myocardial infarction in a total of 1990 patients.

    Journal of clinical pathology·2004
    Same author

    The effect of oral folic acid on glutathione, glycaemia and lipids in Type 2 diabetes.

    Diabetes, nutrition & metabolism·2004

    Serious delayed respiratory depression occurred in patients receiving subarachnoid spinal anesthesia with morphine and bupivacaine. Intravenous naloxone reversed the respiratory depression but not the pain relief.

    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Subarachnoid spinal anesthesia is a common procedure.
    • Morphine is sometimes used as an adjunct for spinal anesthesia to prolong analgesia.

    Observation:

    • Three of six patients developed serious, delayed respiratory depression after receiving subarachnoid spinal anesthesia with morphine and bupivacaine.
    • The respiratory depression episodes were reversed by intravenous naloxone administration.

    Findings:

    • The opioid antagonist naloxone effectively reversed respiratory depression induced by subarachnoid morphine.
    • Naloxone did not antagonize the analgesic effects of morphine, suggesting a differential receptor interaction or distribution.

    Implications:

    • This suggests a potential risk of delayed respiratory depression with intrathecal morphine, even at low doses.

    Related Experiment Videos

  • Careful monitoring for respiratory depression is warranted in patients receiving spinal anesthesia with opioids.
  • Further research into the mechanism of delayed respiratory depression and the differential effects of naloxone on analgesia and respiratory function is needed.