Subacute reactions to intrathecal amipaque (metrizamide), conray and dimer X: a structural and ultrastructural study

Adult New Zealand rabbits were injected intrathecally with 200 or 300 mgI/ml of metrizamide, meglumine iocarmate or meglumine iothalamate. They were placed in the Trendelenburg position for 20 min and allowed to survive for 1, 2 or 3 weeks. Sacrifice was by intraarterial perfusion of aldehydes under anesthesia followed by preparation of brain and major venous sinuses for light and electron microscopy. Major findings were subpial edema and inflammatory reaction of superficial brain, leptomeninges, subarachnoid space and arachnoid granulations. They were most severe after iothalamate and milder after metrizamide. The severity decreased with time. It is of significance that severe reactions occurred after 300 mgI/ml concentration of metrizamide.