[Anti-müllerian hormone and lectins. New perspectives (author's transl)]

Anti-müllerian hormone (AMH), responsible for the regression of müllerian ducts in male fetuses in a glycoprotein. Its affinity towards 7 different lectins has been tested in a density gradient sedimentation system. AMH binds with low affinity to the E subunit of the Phaseolus vulgaris lectin. On the opposite, high affinity binding was observed with wheat germ agglutinin (WGA) and confirmed by affinity chromatography on immobilized WGA. Anti-müllerian activity was totally bound by the column and eluted by N-acetyl-glucosamine. These data confirm the glycoprotein nature of AMH and offer great promise for its purification.