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Extraglomerular dense deposits in dense deposit disease
Archives of Pathology & Laboratory Medicine
|November 1, 1982
Summary
Dense deposit disease (DDD) primarily affects the kidneys. This study found that DDD also involves the spleen, with dense deposits observed in its sinusoidal basement membranes.
Area of Science:
- Nephrology
- Pathology
- Immunology
Background:
- Dense deposit disease (DDD) is a rare kidney disorder.
- The extra-renal manifestations of DDD are not well-understood.
Purpose of the Study:
- To investigate the presence of dense deposits in tissues beyond the kidney in patients with DDD.
Main Methods:
- Electron microscopy was used to examine skin biopsy specimens from DDD patients.
- Autopsy tissues from patients with a history of renal failure were also analyzed.
Main Results:
- Dense deposits were absent in skin biopsies.
- Dense deposits were identified in the spleen's sinusoidal basement membranes in two cases.
- No dense deposits were found in the brain, heart, lungs, liver, adrenals, or pancreas.
Conclusions:
- Dense deposit disease (DDD) affects not only the kidneys but also the spleen.
- The spleen should be considered a potential site for extra-renal manifestations of DDD.