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Patho-physiology of kallikrein system
Annals of Clinical and Laboratory Science
|May 1, 1980
Summary
This study details the contact factors (factor XII, high molecular weight kininogen, prekallikrein), their deficiencies, and interactions. It explores their regulation and measurement, linking them to various diseases and kinin formation.
Area of Science:
- Biochemistry
- Hematology
- Physiology
Background:
- The contact activation system involves factor XII, high molecular weight kininogen, and prekallikrein.
- Hereditary deficiencies in these proteins cause bleeding disorders.
- Plasma proteolytic inhibitors, including Cl inhibitor and antithrombin III, regulate this system.
Purpose of the Study:
- To describe the properties and interactions of contact factors.
- To outline abnormalities in hereditary deficiencies of these proteins.
- To discuss the regulation of the contact system and associated diseases.
Main Methods:
- Review of biochemical properties and interactions of contact factors.
- Discussion of biochemical techniques for measuring the contact system.
- Description of conditions related to abnormal protein synthesis and disease.
Main Results:
- Properties and interactions of factor XII, high molecular weight kininogen, and prekallikrein are detailed.
- Regulation by plasma inhibitors like Cl inhibitor and antithrombin III is delineated.
- Abnormalities, deficiencies, and associated diseases are described.
Conclusions:
- Understanding the contact activation system is crucial for comprehending pathophysiological alterations.
- Further research into this system will enhance knowledge of its role in disease.
- This review provides a comprehensive overview of the contact factors and their clinical relevance.