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Related Experiment Videos

[Elastase activity in experimental pancreatitis].

V A Kubyshkin, I I Musin, R G Ambartsumian

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |October 1, 1980
    PubMed
    Summary

    In experimental pancreatitis, elastase activity significantly increased while elastase inhibitor activity decreased. Liver dysfunction may contribute to reduced elastase inhibition during severe pancreonecrosis.

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    [Ventral hernias and extracellular matrix of connective tissue].

    Khirurgiia·2020

    Area of Science:

    • Biochemistry
    • Veterinary Medicine
    • Pathophysiology

    Context:

    • Investigating biochemical markers in canine experimental pancreatitis.
    • Examining the progression of severe pancreonecrosis in dogs.

    Purpose:

    • To analyze the activity of elastase, elastase inhibitor, and lactate dehydrogenase (LDH) isozymes in experimental pancreatitis.
    • To explore the relationship between these markers and disease progression.

    Summary:

    • Elastase blood activity increased threefold post-pancreatitis induction and remained elevated until death.
    • Elastase inhibitor activity decreased, correlating with increased elastase levels.
    • Lactate dehydrogenase isozyme patterns showed a disproportion between LDH 1 and LDH 2, with an increase in LDH 5.

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    Impact:

    • Suggests liver dysfunction as a potential cause for decreased elastase inhibitory activity in pancreonecrosis.
    • Highlights specific enzyme and isozyme changes indicative of severe pancreatic injury in dogs.