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Complement activation in Staphylococcus aureus bacteraemia.

A F Hallett, R Cooper

    Clinical and Experimental Immunology
    |May 1, 1980
    PubMed
    Summary
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    Staphylococcus aureus bacteraemia can activate the complement system, potentially leading to immune complex disease. High protein A in S. aureus correlates with low C3 levels, indicating complement activation.

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Clinical Microbiology

    Background:

    • Staphylococcus aureus bacteraemia is a serious infection.
    • The complement system plays a crucial role in host defense against bacterial infections.
    • Activation of the complement system can lead to both beneficial and detrimental effects.

    Purpose of the Study:

    • To investigate complement activation in patients with Staphylococcus aureus bacteraemia.
    • To explore the relationship between complement component levels and S. aureus protein A.
    • To assess the potential role of complement activation in the pathogenesis of immune complex disease.

    Main Methods:

    • Measurement of serum complement components (C3, C4, factor B) in 25 patients.
    • Quantification of staphylococcal protein A using indirect haemagglutination.

    Related Experiment Videos

  • Clinical assessment for signs of immune complex disease.

    • Main Results:

    • Depressed C3 levels were observed in 9 patients, with 5 showing low C4, indicating classical pathway activation.
    • Two patients exhibited low C3 and factor B, suggesting both classical and alternative pathway activation.
    • High S. aureus protein A correlated with low C3 levels in patients.
    • Three patients presented with clinical evidence of immune complex disease.

    Conclusions:

    • Complement activation occurs in Staphylococcus aureus bacteraemia, likely via complexes of IgG Fc and staphylococcal protein A.
    • This activation may contribute to the development of immune complex disease in some patients.
    • Understanding complement involvement offers insights into S. aureus infection pathogenesis.